News

Lifelong creatine deficiency leads to augmented sarcoplasmic reticulum calcium release but not heart failure

Jelena Branovets, Martin Laasmaa, Jekaterina Stolova, Xin Shen, Triinu Rätsepso, Romain Bernasconi, Kärol Soodla, Mihkel Jaan Balodis, Cärolin Grahv, Eliise Hendrikson, William Edward Louch...

Compartmentalization in cardiomyocytes modulates creatine kinase and adenylate kinase activities

Rikke Birkedal, Jelena Branovets, Marko Vendelin

FEBS Lett, 2024 Nov; 598(21): 2623-2640.

• PMID: 39112921
• DOI: 10.1002/1873-3468.14994

Significance

Heart muscle cells contain densely pa...

Congratulations to Jelena Branovets, who defended her doctoral thesis, Energetics and Calcium Handling in Hearts from Creatine-Deficient Mice, at TalTech on 29 September 2022.

The creatine kinase system helps the heart match energy production to the energy needed for every contraction. Jelena's...

Cardiac expression and location of hexokinase changes in a mouse model of pure creatine deficiency

Jelena Branovets, Niina Karro, Karina Barsunova, Martin Laasmaa, Craig A Lygate, Marko Vendelin, Rikke Birkedal

Am J Physiol Heart Circ Physiol, 2021 Feb 01; 320(2): H613-H629.

• PMID: 33337958...

Altered calcium handling in cardiomyocytes from arginine-glycine amidinotransferase-knockout mice is rescued by creatine

Martin Laasmaa, Jelena Branovets, Karina Barsunova, Niina Karro, Craig A Lygate, Rikke Birkedal, Marko Vendelin

Am J Physiol Heart Circ Physiol, 2021 Feb 01; 320(2): H805-H82...

Marker enzyme activities in hindleg from creatine-deficient AGAT and GAMT KO mice - differences between models, muscles, and sexes

Karina Barsunova, Marko Vendelin, Rikke Birkedal

Sci Rep, 2020 May 14; 10(1): 7956.

• PMID: 32409787
• DOI: 10.1038/s41598-020-64740-8

Significance

Creati...

Metabolic compartmentation in rainbow trout cardiomyocytes: coupling of hexokinase but not creatine kinase to mitochondrial respiration

Niina Karro, Mervi Sepp, Svetlana Jugai, Martin Laasmaa, Marko Vendelin, Rikke Birkedal

J Comp Physiol B, 2017 Jan; 187(1): 103-116.

• PMID: 27522222
• DOI:...

The location of energetic compartments affects energetic communication in cardiomyocytes

Rikke Birkedal, Martin Laasmaa, Marko Vendelin

Front Physiol, 2014; 5: 376.

• PMID: 25324784
• DOI: 10.3389/fphys.2014.00376

Significance

Heart cells must continuously match energy production to t...

Sensitivity analysis of flux determination in heart by H₂ ¹⁸O -provided labeling using a dynamic Isotopologue model of energy transfer pathways

David W Schryer, Pearu Peterson, Ardo Illaste, Marko Vendelin

PLoS Comput Biol, 2012; 8(12): e1002795.

• PMID: 23236266
• DOI: 10.1371/journal.pcbi...

Molecular dynamics simulations of creatine kinase and adenine nucleotide translocase in mitochondrial membrane patch

Jaanus Karo, Pearu Peterson, Marko Vendelin

J Biol Chem, 2012 Mar 02; 287(10): 7467-76.

• PMID: 22241474
• DOI: 10.1074/jbc.M111.332320

Significance

Mitochondria make t...